Children with CHD are at increased risk for developing severe RSV disease. In fact, children with CHD are 3 to 5 times more likely than lower-risk babies to be admitted to the hospital because of a severe RSV infection.

How do the different types of CHD affect the lungs?

The many types of heart defects generally fall into 3 categories. In each group, a hole in the heart allows blood to flow incorrectly from one area to another. Your doctor may call this “shunting.” Different forms of CHD have different kinds of shunts.

Normal

How blood flows through a normal heart

The heart is a 2-sided pump. The right side of the heart collects oxygen-poor blood from the rest of the body. It pumps that blood to the lungs to pick up oxygen. The oxygen-rich blood returns to the left side of the heart from the lungs. The heart pumps it back throughout the body.

Normal Heart
 
 

Oxygen-rich Blood

 

Oxygen-poor Blood

 

Mixed

 

Left-to-Right

Left-to-Right Shunting

A left-to-right shunt is a heart defect that allows oxygen-rich blood to move from the left side of the heart to the right side.

  • It causes too much blood flow to the lungs.
  • This makes the lungs work harder and makes it hard for the baby to breathe.
Left to Right Shunting
 
 

Oxygen-rich Blood

 

Oxygen-poor Blood

 

Mixed

 

Right-to-Left

Right-to-Left Shunting

A right-to-left shunt is a defect that allows oxygen-poor blood to move from the right side of the heart to the left side and into the circulation.

  • It causes too little blood flow to the lungs.
  • The body does not receive enough oxygenated blood. This causes cyanosis, which can make the baby’s skin appear blue.
Right to Left Shunting
 
 

Oxygen-rich Blood

 

Oxygen-poor Blood

 

Mixed

 

Mixed

Mixing Lesions

A mixing lesion is a defect that has both left-to-right and right-to-left shunting.

  • It causes either too little or too much blood flow to the lungs.

Remember to talk to your doctor if you have questions about SYNAGIS or your baby’s health.

Important Safety Information

Who should not receive SYNAGIS?

Children should not receive SYNAGIS if they have ever had a severe allergic reaction to it. Signs and symptoms of a severe allergic reaction could include itchy rash; swelling of the face; difficulty swallowing; difficulty breathing; bluish color of the skin; muscle weakness or floppiness; and/or unresponsiveness. If your child has any of these signs or symptoms of a severe allergic reaction after getting SYNAGIS, call your child’s healthcare provider or get medical help right away.

How is SYNAGIS given?

SYNAGIS is given as a monthly injection, usually in the thigh (leg) muscle, by your child’s healthcare provider. If your child has a problem with bleeding or bruises easily, an injection could cause a problem. Your child should receive their first injection of SYNAGIS before the RSV season starts, to help protect them before RSV becomes active. RSV season is usually fall through spring, but it may begin earlier or last longer in certain areas. When RSV is most active, your child will need to receive injections of SYNAGIS every 28-30 days to help protect them from severe RSV disease for about a month. Your child should continue to receive monthly injections of SYNAGIS until the end of RSV season. Your child may still get severe RSV disease after receiving SYNAGIS. If your child has an RSV infection, they should continue to get their monthly injections throughout the RSV season to help prevent severe disease from new RSV infections.

The effectiveness of injections of SYNAGIS given less than monthly throughout the RSV season has not been established.

What are the possible side effects of SYNAGIS?

Serious side effects include severe allergic reactions, which may happen after any injection of SYNAGIS and may be life-threatening or cause death. Call your child’s healthcare provider or get medical help right away if your child has any of the signs or symptoms of a serious allergic reaction. See “Who should not receive SYNAGIS?” for more information.

Common side effects of SYNAGIS include fever and rash.

These are not all the possible side effects of SYNAGIS.

APPROVED USE

SYNAGIS is a prescription medication that is used to help prevent a serious lung disease caused by respiratory syncytial virus (RSV) in children:

  • born prematurely (at or before 35 weeks) and who are 6 months of age or less at the beginning of RSV season
  • who have a chronic lung condition called bronchopulmonary dysplasia (BPD), that needed medical treatment within the last 6 months, and who are 24 months of age or less at the beginning of RSV season
  • born with certain types of heart disease and who are 24 months of age or less at the beginning of RSV season

It is not known if SYNAGIS is safe and effective:

  • to treat the symptoms of RSV in a child who already has RSV. SYNAGIS is used to help prevent RSV disease
  • in children who are older than 24 months of age at the start of dosing